Developing robust formulations and manufacturing processes suitable for late phase clinical trials. Interested in Almac’s Whole Exome Sequencing (WES) Service? Figure 1. We can process your gDNA, Blood, Cell line, Fresh frozen tissue, FFPE samples and single cell applications from human and rodents, with the following general requirements: Intact genomic DNA ≥ 1µg, Concentration ≥ 12.5 ng/ µl, Genomic DNA ≥ 200 ng, Concentration ≥ 2.5 ng/ µl. Create a myBGI account to view all our sample and shipping documentation and to manage your project moving forwards. Submit your details below: *By submitting your information you acknowledge that you have read the privacy statement and you consent to our processing the data in accordance with that privacy statement. sheet. Whether you are conducting studies in rare mendelian disorders, complex disease, cancer research, or human population studies, Novogene’s comprehensive human whole exome … Cambridge, MA
Email or call us at 1-877-GENEWIZ (436-3949), Ext. BGI Whole Exome Sequencing services are executed with DNBseq sequencing technology and Illumina sequencing system. Services on the DNBSEQ(TM) platforms are executed at laboratories outside of the USA. performance of the WES service. Our rapid trio “whole” exome sequencing service aims to provide a diagnosis for children with severe paediatric disorders for whom a diagnosis is required more urgently … Integrated API manufacturing solutions throughout the drug development lifecycle. Highly experienced laboratory professionals follow strict quality procedures to ensure the integrity of your results. Note, BGI's genetic testing products have not been cleared or approved by the US FDA and are not available in the USA. For Research Use Only. Whole Exome Sequencing (WES) Service. Associating DNA variants with a phenotype, such as a disease, Discovering biomarkers and therapeutic targets, 100bp and 150bp paired-end sequencing options available, Agilent SureSelect kit, BGI kit, NimbleGen SeqCap or KAPA Hyper Prep kit for library construction and enrichment, Raw data and bioinformatics analysis are available in standard file formats, Advanced and custom bioinformatics data analysis available, Cloud-based data storage and delivery system, Guaranteed ≥ 80% of bases with quality score of ≥Q30, Standard sequencing coverage ≥50X; ≥150X is recommended for cancer samples. Expert development & manufacturing solutions for all phases of clinical trials, Providing a range of solid oral dose development and manufacturing services from 3 state-of-the-art facilities. Whole Exome Sequencing (WES) Service Almac’s high quality, robust WES Next Generation Sequencing (NGS) solution is built on Agilent’s chemistry with sequencing performed … BGI has performed professional sequencing services for many years at multiple locations globally, to support biomedical research and to benefit small and large-scale clinical trials and other projects in pharmaceutical drug development. technology, followed by high-resolution digital imaging. Exome sequencing, also known as whole exome sequencing, is a genomic technique for sequencing all of the protein-coding regions of genes in a genome. 02142 USA. Exome Sequencing provides a cost and time effective alternate to whole genome sequencing. Ask your BGI representative about our current introductory pricing for Whole Exome Sequencing with the BGI’s own DNBseq technology. Diagnostic Services / Typical 40 working days from sample QC acceptance to filtered raw data availability. Fine chemical manufacture for pharmaceutical & health care, flavour/ fragrance and more, Almac’s continuous flow technology platform enables access to better synthetic strategies. Over 50 years’ experience manufacturing solid oral dosage forms. The human exome represents less than 2% of the genome, but contains ~85% of known disease-related variants, 1 making this method a cost-effective alternative to whole-genome sequencing. Whole exome sequencing (WES) is especially suitable for patients who are looking for a unifying diagnosis for multiple medical problems. This website contains information on products which is targeted to a wide range of audiences and could contain product details or information otherwise not accessible or valid in your country. Almac Sciences’ innovative virtual tour solution digitises conventional on-site client tours and audits. Almac analytical validation data confirms the highly accurate, repeatable and reproducible Whole Exome Sequencing is gaining popularity as a viable and cost-effective alternative to Whole Genome Sequencing: WES targets all protein-coding regions (~1% of the … Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. CopyrightⒸ BGI 2021. Most … Whole exome sequencing is a cost-effective and powerful tool, especially suitable for bigger sample size and high coverage. Please try again. It's quick, free and easy! Using a 33Mb design (37Mb sequencing footprint) covering 99% of ClinVar variants, we achieve coverage of >97% of targeted regions at >= 20x coverage with a 150x mean sequencing depth and requiring just 4.90Gb of sequencing … Clinical whole-exome sequencing is a routine option for diagnostics tests to help provide deeper insights into your personal health. Whole-exome sequencing is a widely used next-generation sequencing (NGS) method that involves sequencing the protein-coding regions of the genome. Flexibility, cost and time are key criteria in evaluating options in a ‘build or buy’ decision for your technology. Whoops! Exome Sequencing is fast, cost effective and generates a smaller sized data for quick analysis. It consists of two steps: the … Targeting only … Sequencing Service Offerings We offer access to fast, high-quality, sample-to-data next-generation sequencing (NGS) services such as RNA and whole-genome sequencing … Learn more about your customer service options. Send us a no obligation request for quote and our dedicated sales team will reply to you within 24 hours. Extensive experience in QC and Analytical Support, Almac’s expertise ranges from enzyme production to the synthesis of complex chrial APIs, A range of peptide & protein services from early phase to commercial launch. Something went wrong. Application of whole exome sequencing … But … Technical Specification and Performance Validation: Bioinformatics, Biostatistics & Software Development, A unique culture delivering exceptional solutions, API Development and Manufacture – Early Phase, API Development and Manufacture – Late Phase, Antibody (or protein) Drug Conjugates (ADCs), Human site-specifically biotin labelled Chemokines, Reference Standard Preparation and Characterisation, Our Pharmaceutical Development Facilities, formufast™: Pre-Clinical Formulation Development, The Physical and Digital Clinical Supply Chain, Secondary Labelling and Kitting of Clinical Supplies, Almac Adapt™ Just in Time Manufacturing Solution, Clinical Returns, Accountability and Destruction, Almac ONE™ – Unified Clinical Trial Supply Solution, ART™ – Accountability & Reconciliation Tracking, Pharmaceutical Product Launch & Distribution. WGS focuses on the whole genome, specifically the exons … Almac’s high quality, robust WES Next Generation Sequencing (NGS) solution is built on Agilent’s chemistry with sequencing performed on the Illumina NovaSeq or NextSeq technology. BGI Whole Exome Sequencing services are executed with the Illumina sequencing system, or exclusively with our DNBSEQ™ NGS platform , for great sequencing data at the … ExomeSeq is a test that looks at most of the genes. Whole exome sequencing. Whole exome sequencing is mainly used to investigate the genetic cause of both Mendelian and common diseases such as cancer and diabetes. With you for the journey™. Exome sequencing offers an efficient … In addition to raw data output, BGI offers a range of standard and customized bioinformatics pipelines for your whole genome sequencing project. BGI Whole Exome Sequencing services are executed with the Illumina sequencing system, or exclusively with DNBseq sequencing technology, for great sequencing data at the lowest cost in the industry. Whole Genome Sequencing (WGS) and Whole Exome Sequencing (WES) are increasingly clinically available due to significant advances in DNA sequencing technology over the last several years … Based on this advanced platform, we can provide the most comprehensive cancer WGS sequencing … CLIA whole genome sequencing is available for more comprehensive genomic analysis. In 2018, whole exome sequencing (WES) was first scheduled for assessment in conjunction with genomic … Overview Exome Sequencing is a method that selectively analyzes only coding region (Exon), which composes 1-2% of the genome. Exome sequencing is often ordered when individuals present with complex, often syndromic symptoms that have a suspected genetic etiology. Comprehensive range of Chemokine and Histone products with worldwide shipping and online discounts available. Use our quick contact form below. SNP functionality and conservation prediction, Statistics of SNP distribution on each gene functional element, Statistics of InDel distribution on each gene functional element, De novo mutation analysis for family samples, Further customization of Bioinformatics analysis to suit your unique project is available: Please contact your BGI technical representative, One Broadway, 3rd Floor,
With its announced launch of a whole-exome sequencing service for apparently healthy individuals, Ambry Genetics is the latest company to enter this growing market. We care for your samples from the start through to the result reporting. Oral dose formulations to support your early phase clinical trials. Reports and output data files are delivered in industry standard file formats: BAM,.xls, and .png. 1 for a technical consultation on our service … If you change your mind at any time about wishing to receive material from us, you can send an email to [email protected]. Thank you! The dual DNA and RNA extraction protocol facilitates simultaneous generation of WES and RNA Exome data from a single FFPE sample. Every email we send you will also include an unsubscribe link so you can unsubscribe from our marketing list. Providing services for all stages of drug development for small (including highly potent) molecules and peptides. Efficient, flexible and innovative global packaging solutions, Extensive global secondary clinical packaging solutions, Changes to your clinical supply landscape require a quicker response and greater flexibility, A global distribution solution to safeguard your patients and clinical trials. We may, from time to time, send you material relevant to your interests. Have a general question about your project or want pricing information? Almac Diagnostic Services has received R&D funding from Invest Northern Ireland and the European Regional Development Fund to support the development of this service. With years of research and … This system is powered by combinatorial Probe-Anchor Synthesis (cPAS), linear isothermal Rolling-Circle Replication and DNA Nanoballs (DNBTM) technology, followed by high-resolution digital imaging. Delivering comprehensive solutions to support drug substance (API) and drug product development programs. DNBseq is a high-throughput sequencing platform developed by a subsidiary of BGI, Complete Genomics, in Silicon Valley. Thank you, your sign-up request was successful! Creative Biolabs has established the high-throughput SuPrecision™ platform for large-scale sequencing services. Not for use in diagnostic procedures (except as specifically noted). Human exome sequencing generated about 5 Gb of data as compared to 90Gb per whole … This system is powered by combinatorial Probe-Anchor Synthesis (cPAS), linear isothermal Rolling-Circle Replication and DNA Nanoballs (DNB. ) For many applications, Whole Exome Sequencing is gaining popularity as a viable and cost-effective alternative for Whole Genome Sequencing. In applications requiring greater sequencing depth than is practical with WGS, such as whole-exome sequencing (WES) and customized or disease-specific sequencing panels, this type of … DNBseq is a high-throughput sequencing platform developed by a subsidiary of BGI, Complete Genomics, in Silicon Valley. The platform covers 99.7% of coding exons with readily interpretable raw sequencing data for use in biomarker discovery and retrospective clinical investigation. Whole exome sequencing (WES) is a powerful tool to investigate genetic variations underlying cancers, Mendelian diseases, and complex human disorders. The goal of the NHLBI GO Exome Sequencing Project (ESP) is to discover novel genes and mechanisms contributing to heart, lung and blood disorders by pioneering the application of next-generation sequencing … We'll aim to respond within the day. Whole genome sequencing (WGS) is a key driver for many medical research projects in cancer and complex genetic disorders. Description of Whole Exome Sequencing Whole Exome Sequencing (WES) focuses on protein-coding genes to identify etiological variants in diseases such as hereditary genetic disorders … It is a cheaper and effective way of sequencing … Global blinding experience across a range of investigational medicinal products. Besides raw sequencing data output, BGI offers standard and custom bioinformatics services to suit your specific research needs. Your enquiry has been submitted successfully. The Cell3 Target Whole Exome focuses on the core protein-coding regions referenced in CCDS. By continuing to browse the site, you are agreeing to our. This test may be useful for patients whose medical and family histories suggest a genetic cause for their signs and symptoms. Expert Qualified Persons (QPs) and an experienced support team for your trial, Alignment between the digital and physical clinical trial supply chain, Unlock new efficiencies through industry-leading technology, An intuitive and logical way to manage the key components of clinical trials, Trust our industry-leading experts for better trial outcomes, Utilise Almac’s industry leading IRT – submit your IRT request for immediate review, Clinical Technologies Podcast: Spotlight on IRT, Commercial manufacturing, packaging, distribution & product launch services, Helping you successfully launch your orphan drug products in to the EU market. For more information click here. Almac’s wet lab optimised workflow generates comprehensive WES data from multiple sample types, including more challenging Formalin Fixed Paraffin Embedded (FFPE) material. Whole Exome Sequencing by the Molecular Genetics Laboratory The Molecular Genetics Laboratory at Cincinnati Children's offers ExomeSeq, a clinical whole exome sequencing test … From initial artwork and pack design, to commercial packaging and serialisation, Paediatric solutions from development to commercialisation, Supporting clients in developing their serialisation strategies to GS1 standards, A range of storage conditions and flexible distribution solutions to meet your needs, View our HPRA approved European campus based in Dundalk, Ireland, This website uses cookies. For full technical specification & further validation information download the fact DUBLIN, Jan. 27, 2021 /PRNewswire/ -- The "Whole Genome And Exome Sequencing Markets - By Research, Clinical, Direct to Consumer, AgriBio & Tumor with … Delivering a diverse range of chemistry testing services across a diverse industry base, Providing top quality, specialist analysis from discovery to pivotal clinical studies, Comprehensive and flexible analytical solutions, Experts in cGMP microbiology testing of raw materials, finished products & water systems, Skilfully guiding you to make the right decisions at the right time, The most comprehensive Global Clinical Supply Chain Solution in the marketplace, Latest updates and resources from Almac Clinical Services, Global sourcing of comparator and commercial products for clinical trials, Navigating the complexities of the clinical supply chain. All your temperature data, for all your products, in one place. All trademarks are the property of BGI, or their respective owners. BGI Whole Exome Sequencing services are executed with the Illumina sequencing system, or exclusively with DNBseq sequencing technology, for great sequencing data at the … Expedited services are available, contact your local BGI specialist for details, Real-Time Fluorescent RT-PCR Kit for Detecting SARS-CoV-2 (FDA EUA), High Throughput Lab Solution for COVID-19 Testing. Biomarker Discovery, Assay Development & Validation, CDx Development, Project Management, Regulatory Advice, Bioinformatics & Biostatistics, State-of-the-art laboratories based in the UK, US and a partner lab in Asia, Novel DNA & RNA panel solutions for complex biomarker-led clinical trials, Stay up to date with Almac Diagnostics news, events & resources, Learn more about our leadership team, history and The Almac Group, Partner with us for your Biomarker Discovery & Clinical Trials. 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